Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.

Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.

Blog Article

Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal.Therapy with amina muaddi scarpe trasparenti tumor-selective viruses is emerging as a treatment option for this devastating disease.In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors.VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro.

In vivo, in two different orthotopic glioma models, a puffy spa headband single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free of disease.